From the News & Observer:
Why do some people need 10 cups of coffee just to make it through the day, while others feel wired from just one cup?Part of the answer may be in your genes.Researchers from UNC-Chapel Hill, the Harvard School of Public Health, and five other institutions have pinpointed two genetic variants that may help explain why some people crave more caffeine than others.Read the full article
...One of the variants was located near a gene called CYP1A2, which plays a role in caffeine metabolism, and the second was near a gene dubbed AHR, which regulates CYP1A2.While everyone has two copies of each of these genes - one inherited from each parent - the copies vary subtly from one person to the next.
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